Imaging CXCR4 Expression in Human Cancer Xenografts: Evaluation of Monocyclam 64Cu-AMD3465
نویسندگان
چکیده
منابع مشابه
Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography.
The chemokine receptor CXCR4 and its cognate ligand CXCL12 are pivotal for establishing metastases from many tumor types. Thus, CXCR4 may offer a cell surface target for molecular imaging of metastases, assisting diagnosis, staging, and therapeutic monitoring. Furthermore, noninvasive detection of CXCR4 status of a primary tumor may provide an index of the metastatic potential of the lesion. He...
متن کاملMolecular Imaging of CXCR4 Receptor Expression in Human Cancer Xenografts with [Cu]AMD3100 Positron Emission Tomography
Authors' A Radiologica Note: Sup Research O Correspon Institutions Phone: 410
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Background The chemokine receptor 4 (CXCR4) is an important molecular target for both visualization and therapy of tumors. The aim of the present study was the synthesis and preclinical evaluation of a 64Cu-labeled, CXCR4-targeting peptide for positron emission tomography (PET) imaging of CXCR4 expression in vivo. Methods For this purpose, 1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic ac...
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Liposomes (LP) deliver drug to tumors due to enhanced permeability and retention (EPR). LP were labeled with 64Cu for positron emission tomography (PET) to image tumor localization. Bevacizumab (bev), a VEGF targeted antibody, may modify LP delivery by altering tumor EPR and this change can also be imaged. Objective: Assess the utility of 64Cu-labeled LP for PET in measuring altered LP delivery...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2011
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.110.085613